# Conjugation Chemistry Markedly Impacts Toxicity and Biodistribution of Targeted Nanoparticles, Mediated by Complement Activation

*PRI Rank #18 · Topics and Trends in Most Cited Monoclonal and Polyclonal Antibodies Research Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/monoclonal-and-polyclonal-antibodies-research/2026/rank-18*

| Field | Value |
| --- | --- |
| Rank | #18 |
| 18m citations | 43 |
| Journal | Advanced Materials |
| Year | 2024 |
| DOI | 10.1002/adma.202409945 |
| Corresponding authors | Jacob W. Myerson, Jacob S. Brenner |
| Institution | University of Pennsylvania, United States |

**Ranking page:** [Topics and Trends in Most Cited Monoclonal and Polyclonal Antibodies Research Papers, Class of 2026](https://pri.pepkio.com/top-papers/monoclonal-and-polyclonal-antibodies-research/2026)

**Paper link:** [10.1002/adma.202409945](https://doi.org/10.1002/adma.202409945)

## Topics

antibody-targeted lipid nanoparticles · Bioconjugation chemistry · complement activation · antibody-drug conjugate · biodistribution changes · phagocyte uptake in lungs · platelet count reduction · dibenzocyclooctyne click chemistry · thiol-maleimide chemistry · antibody aggregation on nanoparticle surface · free maleimide-albumin conjugation · albumin clustering · complement cascade of plasma proteins · opsonization · nanomedicine toxicity · drug delivery systems · COVID-19 vaccine-inspired lipid nanoparticles · engineered chemistry solutions to reduce complement activation

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Monoclonal and Polyclonal Antibodies Research Papers, Class of 2026. https://pri.pepkio.com/top-papers/monoclonal-and-polyclonal-antibodies-research/2026. Accessed 2026-07-15.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```