# A unique serum IgG glycosylation signature predicts development of Crohn’s disease and is associated with pathogenic antibodies to mannose glycan

*PRI Rank #17 · Topics and Trends in Most Cited Monoclonal and Polyclonal Antibodies Research Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/monoclonal-and-polyclonal-antibodies-research/2026/rank-17*

| Field | Value |
| --- | --- |
| Rank | #17 |
| 18m citations | 43 |
| Journal | Nature Immunology |
| Year | 2024 |
| DOI | 10.1038/s41590-024-01916-8 |
| Corresponding authors | Salomé S. Pinho |
| Institution | University of Porto, Portugal |

**Ranking page:** [Topics and Trends in Most Cited Monoclonal and Polyclonal Antibodies Research Papers, Class of 2026](https://pri.pepkio.com/top-papers/monoclonal-and-polyclonal-antibodies-research/2026)

**Paper link:** [10.1038/s41590-024-01916-8](https://doi.org/10.1038/s41590-024-01916-8)

## Topics

Fc glycosylation · agalactosylation · anti-Saccharomyces cerevisiae antibodies (ASCA) · PREDICTS cohort · preclinical Crohn's disease phase · IgG2 Fc glycan trait · mannose glycan recognition · FcγR-dependent signaling · NF-κB signaling · CARD9 signaling · inflammasome activation · dendritic cell reprogramming · natural killer cell activation · adoptive antibody transfer mouse model · FcγR-deficient mice · anti-mannan antibodies · glycome-ASCA hub · serum biomarker for disease prediction · intestinal inflammation susceptibility · proinflammatory antibody glycoform

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Monoclonal and Polyclonal Antibodies Research Papers, Class of 2026. https://pri.pepkio.com/top-papers/monoclonal-and-polyclonal-antibodies-research/2026. Accessed 2026-07-15.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```