# De novo generation of SARS-CoV-2 antibody CDRH3 with a pre-trained generative large language model

*PRI Rank #12 · Topics and Trends in Most Cited Monoclonal and Polyclonal Antibodies Research Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/monoclonal-and-polyclonal-antibodies-research/2026/rank-12*

| Field | Value |
| --- | --- |
| Rank | #12 |
| 18m citations | 49 |
| Journal | Nature Communications |
| Year | 2024 |
| DOI | 10.1038/s41467-024-50903-y |
| Corresponding authors | Bing He, Calvin Yu‐Chian Chen, Ting Li, Jianhua Yao |
| Institution | Tencent, China |

**Ranking page:** [Topics and Trends in Most Cited Monoclonal and Polyclonal Antibodies Research Papers, Class of 2026](https://pri.pepkio.com/top-papers/monoclonal-and-polyclonal-antibodies-research/2026)

**Paper link:** [10.1038/s41467-024-50903-y](https://doi.org/10.1038/s41467-024-50903-y)

## Topics

PALM-H3 · CDR3 · generative large language model · A2binder · antibody-antigen binding prediction · SARS-CoV-2 spike protein · XBB · antibody-antigen binding prediction · antibody-antigen binding prediction · neutralization capability · Roformer architecture · attention mechanism interpretability · in-silico antibody design · artificial antibody generation · antigen specificity · Alpha variant · Delta variant · wild-type SARS-CoV-2 · antibody language model · CDR3

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Monoclonal and Polyclonal Antibodies Research Papers, Class of 2026. https://pri.pepkio.com/top-papers/monoclonal-and-polyclonal-antibodies-research/2026. Accessed 2026-07-15.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```