# mRNA-LNP HIV-1 trimer boosters elicit precursors to broad neutralizing antibodies

*PRI Rank #10 · Topics and Trends in Most Cited Monoclonal and Polyclonal Antibodies Research Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/monoclonal-and-polyclonal-antibodies-research/2026/rank-10*

| Field | Value |
| --- | --- |
| Rank | #10 |
| 18m citations | 50 |
| Journal | Science |
| Year | 2024 |
| DOI | 10.1126/science.adk0582 |
| Corresponding authors | Zhenfei Xie, Ying‐Cing Lin, Jon M. Steichen, Gabriel Ozorowski, Andrew B. Ward, William R. Schief, Facundo D. Batista |
| Institution | The Ragon Institute of Mass General, MIT, and Harvard, United States |

**Ranking page:** [Topics and Trends in Most Cited Monoclonal and Polyclonal Antibodies Research Papers, Class of 2026](https://pri.pepkio.com/top-papers/monoclonal-and-polyclonal-antibodies-research/2026)

**Paper link:** [10.1126/science.adk0582](https://doi.org/10.1126/science.adk0582)

## Topics

mRNA-LNP delivery · Germline-targeting immunogen · N332-GT5 · Broadly neutralizing antibodies · V3-glycan epitope · Humanized mouse model · memory B cells · germinal center reaction · epitope analysis · B cell receptor modification · somatic hypermutation · affinity maturation · prime-boost immunization strategy · off-target V1-binding responses · precursor B cells · HIV vaccine design · lipid nanoparticle formulation · cross-reactivity minimization · protein trimer immunogen design · Broadly neutralizing antibodies

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Monoclonal and Polyclonal Antibodies Research Papers, Class of 2026. https://pri.pepkio.com/top-papers/monoclonal-and-polyclonal-antibodies-research/2026. Accessed 2026-07-15.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```