# Whole-brain spatial transcriptional analysis at cellular resolution

*PRI Rank #9 · Topics and Trends in Most Cited Molecular Biology Techniques and Applications Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/molecular-biology-techniques-and-applications/2026/rank-9*

| Field | Value |
| --- | --- |
| Rank | #9 |
| 18m citations | 58 |
| Journal | Science |
| Year | 2024 |
| DOI | 10.1126/science.adn9947 |
| Corresponding authors | Shigeaki Kanatani, Judith C. Kreutzmann, Yue Li, Zoe West, Per Uhlén |
| Institution | Karolinska Institutet, Sweden |

**Ranking page:** [Topics and Trends in Most Cited Molecular Biology Techniques and Applications Papers, Class of 2026](https://pri.pepkio.com/top-papers/molecular-biology-techniques-and-applications/2026)

**Paper link:** [10.1126/science.adn9947](https://doi.org/10.1126/science.adn9947)

## Topics

TRISCO · tissue-clearing method · whole-brain 3D RNA imaging · in situ hybridization chain reaction · Spatial transcriptomics · RNA integrity preservation · uniform RNA labeling · tissue transparency enhancement · cell-identity markers · Non-coding RNAs · activity-dependent RNAs · single-cell resolution · intact tissue volumes · Tris buffer-mediated retention · cleared organs

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Molecular Biology Techniques and Applications Papers, Class of 2026. https://pri.pepkio.com/top-papers/molecular-biology-techniques-and-applications/2026. Accessed 2026-07-24.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```