# Prediction of plasma ctDNA fraction and prognostic implications of liquid biopsy in advanced prostate cancer

*PRI Rank #7 · Topics and Trends in Most Cited Molecular Biology Techniques and Applications Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/molecular-biology-techniques-and-applications/2026/rank-7*

| Field | Value |
| --- | --- |
| Rank | #7 |
| 18m citations | 67 |
| Journal | Nature Communications |
| Year | 2024 |
| DOI | 10.1038/s41467-024-45475-w |
| Corresponding authors | Matti Annala, Kim N., Alexander W. Wyatt |
| Institution | University of British Columbia, Canada |

**Ranking page:** [Topics and Trends in Most Cited Molecular Biology Techniques and Applications Papers, Class of 2026](https://pri.pepkio.com/top-papers/molecular-biology-techniques-and-applications/2026)

**Paper link:** [10.1038/s41467-024-45475-w](https://doi.org/10.1038/s41467-024-45475-w)

## Topics

Circulating tumor DNA fraction · Circulating tumor DNA fraction · Metastatic castration-resistant prostate cancer (mCRPC) · Metastatic castration-resistant prostate cancer (mCRPC) · liquid biopsy · overall survival · progression-free survival · treatment response prediction · liver metastases · disease burden metrics · ctDNA genotyping · risk stratification · Machine learning prediction model · plasma samples · randomized phase II trials · blood biobanking · clinical prognostic factors · biomarker testing optimization

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Molecular Biology Techniques and Applications Papers, Class of 2026. https://pri.pepkio.com/top-papers/molecular-biology-techniques-and-applications/2026. Accessed 2026-07-24.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```