# Spatially exploring RNA biology in archival formalin-fixed paraffin-embedded tissues

*PRI Rank #5 · Topics and Trends in Most Cited Molecular Biology Techniques and Applications Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/molecular-biology-techniques-and-applications/2026/rank-5*

| Field | Value |
| --- | --- |
| Rank | #5 |
| 18m citations | 75 |
| Journal | Cell |
| Year | 2024 |
| DOI | 10.1016/j.cell.2024.09.001 |
| Corresponding authors | Zhiliang Bai, Mingyao Li, Yi Xing, Jun Lü, Mina L. Xu, Rong Fan |
| Institution | Yale University, United States |

**Ranking page:** [Topics and Trends in Most Cited Molecular Biology Techniques and Applications Papers, Class of 2026](https://pri.pepkio.com/top-papers/molecular-biology-techniques-and-applications/2026)

**Paper link:** [10.1016/j.cell.2024.09.001](https://doi.org/10.1016/j.cell.2024.09.001)

## Topics

Patho-DBiT · FFPE tissue · FFPE tissue · deterministic barcoding in tissue · in situ polyadenylation · Spatial transcriptomics · RNA processing · splicing isoforms · single-nucleotide RNA variants · malignant subclones · human lymphomas · microRNA regulatory networks · RNA splicing dynamics · spatial tumorigenesis · Single-cell spatial transcriptomics · tumor clonal architecture · spatiotemporal cellular dynamics · clinical tumor tissues · archival tissue analysis

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Molecular Biology Techniques and Applications Papers, Class of 2026. https://pri.pepkio.com/top-papers/molecular-biology-techniques-and-applications/2026. Accessed 2026-07-24.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```