# Single-shot 20-fold expansion microscopy

*PRI Rank #20 · Topics and Trends in Most Cited Molecular Biology Techniques and Applications Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/molecular-biology-techniques-and-applications/2026/rank-20*

| Field | Value |
| --- | --- |
| Rank | #20 |
| 18m citations | 30 |
| Journal | Nature Methods |
| Year | 2024 |
| DOI | 10.1038/s41592-024-02454-9 |
| Corresponding authors | Laura L. Kiessling, Edward S. Boyden |
| Institution | Massachusetts Institute of Technology, United States |

**Ranking page:** [Topics and Trends in Most Cited Molecular Biology Techniques and Applications Papers, Class of 2026](https://pri.pepkio.com/top-papers/molecular-biology-techniques-and-applications/2026)

**Paper link:** [10.1038/s41592-024-02454-9](https://doi.org/10.1038/s41592-024-02454-9)

## Topics

Expansion microscopy · Expansion microscopy (ExM) · 20ExM · single-shot expansion · 20-fold linear expansion · isotropic physical magnification · nanoimaging · iterative expansion · postexpansion staining · brain tissue · biomolecular labeling · 20-nm resolution · conventional microscopes

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Molecular Biology Techniques and Applications Papers, Class of 2026. https://pri.pepkio.com/top-papers/molecular-biology-techniques-and-applications/2026. Accessed 2026-07-24.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```