# High-dimensional phenotyping to define the genetic basis of cellular morphology

*PRI Rank #19 · Topics and Trends in Most Cited Molecular Biology Techniques and Applications Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/molecular-biology-techniques-and-applications/2026/rank-19*

| Field | Value |
| --- | --- |
| Rank | #19 |
| 18m citations | 30 |
| Journal | Nature Communications |
| Year | 2024 |
| DOI | 10.1038/s41467-023-44045-w |
| Corresponding authors | Shantanu Singh, Ralda Nehme, Soumya Raychaudhuri |
| Institution | Broad Institute of MIT and Harvard, United States |

**Ranking page:** [Topics and Trends in Most Cited Molecular Biology Techniques and Applications Papers, Class of 2026](https://pri.pepkio.com/top-papers/molecular-biology-techniques-and-applications/2026)

**Paper link:** [10.1038/s41467-023-44045-w](https://doi.org/10.1038/s41467-023-44045-w)

## Topics

Cell morphological quantitative trait loci (cmQTLs) · Cell morphological quantitative trait loci (cmQTLs) · high-content imaging · Induced pluripotent stem cells (iPSCs) · Induced pluripotent stem cells (iPSCs) · rare protein altering variants · WASF2 · TSPAN15 · PRLR · cell shape · nucleic granularity · mitochondrial distribution · CRISPRi knockdown · Deep phenotyping · Morphological profiling · common variant association · sample size prediction · Genomic sequencing · Morphological profiling

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Molecular Biology Techniques and Applications Papers, Class of 2026. https://pri.pepkio.com/top-papers/molecular-biology-techniques-and-applications/2026. Accessed 2026-07-24.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```