# Virtual formalin-fixed and paraffin-embedded staining of fresh brain tissue via stimulated Raman CycleGAN model

*PRI Rank #14 · Topics and Trends in Most Cited Molecular Biology Techniques and Applications Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/molecular-biology-techniques-and-applications/2026/rank-14*

| Field | Value |
| --- | --- |
| Rank | #14 |
| 18m citations | 44 |
| Journal | Science Advances |
| Year | 2024 |
| DOI | 10.1126/sciadv.adn3426 |
| Corresponding authors | Zhijie Liu, Lingchao Chen, Haixia Cheng, Minbiao Ji |
| Institution | Fudan University, China |

**Ranking page:** [Topics and Trends in Most Cited Molecular Biology Techniques and Applications Papers, Class of 2026](https://pri.pepkio.com/top-papers/molecular-biology-techniques-and-applications/2026)

**Paper link:** [10.1126/sciadv.adn3426](https://doi.org/10.1126/sciadv.adn3426)

## Topics

stimulated Raman scattering microscopy · CycleGAN · Virtual histology · formalin-fixed and paraffin-embedded staining · Hematoxylin and eosin staining · intraoperative histology · fresh brain tissue · frozen section · semi-supervised learning · unpaired training data · glioma · neuropathology · lipid/protein contrast · nucleic acid staining · rapid tissue imaging · surgical guidance · histologic subtyping

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Molecular Biology Techniques and Applications Papers, Class of 2026. https://pri.pepkio.com/top-papers/molecular-biology-techniques-and-applications/2026. Accessed 2026-07-24.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```