# Mitotic chromosomes are self-entangled and disentangle through a topoisomerase-II-dependent two-stage exit from mitosis

*PRI Rank #14 · Topics and Trends in Most Cited Microtubule and mitosis dynamics Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/microtubule-and-mitosis-dynamics/2026/rank-14*

| Field | Value |
| --- | --- |
| Rank | #14 |
| 18m citations | 29 |
| Journal | Molecular Cell |
| Year | 2024 |
| DOI | 10.1016/j.molcel.2024.02.025 |
| Corresponding authors | Leonid A. Mirny, Job Dekker |
| Institution | University of Massachusetts Chan Medical School, United States |

**Ranking page:** [Topics and Trends in Most Cited Microtubule and mitosis dynamics Papers, Class of 2026](https://pri.pepkio.com/top-papers/microtubule-and-mitosis-dynamics/2026)

**Paper link:** [10.1016/j.molcel.2024.02.025](https://doi.org/10.1016/j.molcel.2024.02.025)

## Topics

Hi-C · Polymer modeling · multi-contact 3C · mitotic chromosomes · chromosome entanglements · interphase chromosomes · topoisomerase II · mitotic exit · anaphase · telophase · early G1 · chromosome decondensation · condensin loops · decatenation · entropic forces · chromosome territoriality · topological state of chromosomes · two-stage disentanglement pathway

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Microtubule and mitosis dynamics Papers, Class of 2026. https://pri.pepkio.com/top-papers/microtubule-and-mitosis-dynamics/2026. Accessed 2026-09-06.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```