# Paradoxical Activation of Oncogenic Signaling as a Cancer Treatment Strategy

*PRI Rank #13 · Topics and Trends in Most Cited Microtubule and mitosis dynamics Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/microtubule-and-mitosis-dynamics/2026/rank-13*

| Field | Value |
| --- | --- |
| Rank | #13 |
| 18m citations | 29 |
| Journal | Cancer Discovery |
| Year | 2024 |
| DOI | 10.1158/2159-8290.cd-23-0216 |
| Corresponding authors | John S Kovach |
| Institution | Lixte Biotechnology Holdings, Inc., United States |

**Ranking page:** [Topics and Trends in Most Cited Microtubule and mitosis dynamics Papers, Class of 2026](https://pri.pepkio.com/top-papers/microtubule-and-mitosis-dynamics/2026)

**Paper link:** [10.1158/2159-8290.cd-23-0216](https://doi.org/10.1158/2159-8290.cd-23-0216)

## Topics

paradoxical activation · Oncogenic signaling · cancer homeostasis · protein phosphatase 2A (PP2A) · PP2A inhibition · WEE1 · WEE1 · Colorectal cancer · stress response programs · DNA replication collapse · premature mitosis · Synthetic lethality · patient-derived tumors · tumor-suppressive resistance · acquired resistance · oncogenic capacity loss · compound screens · genetic screens

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Microtubule and mitosis dynamics Papers, Class of 2026. https://pri.pepkio.com/top-papers/microtubule-and-mitosis-dynamics/2026. Accessed 2026-07-23.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```