# Exosome circATP8A1 induces macrophage M2 polarization by regulating the miR-1-3p/STAT6 axis to promote gastric cancer progression

*PRI Rank #4 · Topics and Trends in Most Cited MicroRNA in disease regulation Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/microrna-in-disease-regulation/2026/rank-4*

| Field | Value |
| --- | --- |
| Rank | #4 |
| 18m citations | 83 |
| Journal | Molecular Cancer |
| Year | 2024 |
| DOI | 10.1186/s12943-024-01966-4 |
| Corresponding authors | Leli Zeng, Jia Li, Changhua Zhang, Hengxing Chen |
| Institution | Sun Yat-Sen University, China |

**Ranking page:** [Topics and Trends in Most Cited MicroRNA in disease regulation Papers, Class of 2026](https://pri.pepkio.com/top-papers/microrna-in-disease-regulation/2026)

**Paper link:** [10.1186/s12943-024-01966-4](https://doi.org/10.1186/s12943-024-01966-4)

## Topics

circATP8A1 · exosomes · M2 macrophage polarization · miR-1-3p · STAT6 pathway · gastric cancer · tumor microenvironment · Circular RNA · Competing endogenous RNA · Fluorescence In Situ Hybridization · RNA immunoprecipitation · RNA pulldown · Luciferase reporter assay · TNM stage · cancer cell-macrophage communication · tumor-associated macrophages · Prognostic biomarker · Cell invasion

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited MicroRNA in disease regulation Papers, Class of 2026. https://pri.pepkio.com/top-papers/microrna-in-disease-regulation/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```