# CircPPAP2B controls metastasis of clear cell renal cell carcinoma via HNRNPC-dependent alternative splicing and targeting the miR-182-5p/CYP1B1 axis

*PRI Rank #20 · Topics and Trends in Most Cited MicroRNA in disease regulation Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/microrna-in-disease-regulation/2026/rank-20*

| Field | Value |
| --- | --- |
| Rank | #20 |
| 18m citations | 37 |
| Journal | Molecular Cancer |
| Year | 2024 |
| DOI | 10.1186/s12943-023-01912-w |
| Corresponding authors | Fei Li, Wanlong Tan |
| Institution | Southern Medical University, China |

**Ranking page:** [Topics and Trends in Most Cited MicroRNA in disease regulation Papers, Class of 2026](https://pri.pepkio.com/top-papers/microrna-in-disease-regulation/2026)

**Paper link:** [10.1186/s12943-023-01912-w](https://doi.org/10.1186/s12943-023-01912-w)

## Topics

circPPAP2B · clear cell renal cell carcinoma · HNRNPC · alternative splicing · miR-182-5p · CYP1B1 · m6A-dependent interaction · HNRNPC nuclear translocation · nondegradable ubiquitination · HNRNPC/Vimentin/Importin α7 ternary complex · PTBP1 · HNPNPK · miRNA sponge · RNA pulldown · MeRIP · RNA immunoprecipitation · RNA sequencing · metastatic ccRCC

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited MicroRNA in disease regulation Papers, Class of 2026. https://pri.pepkio.com/top-papers/microrna-in-disease-regulation/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```