# Engineered extracellular vesicles for targeted reprogramming of cancer-associated fibroblasts to potentiate therapy of pancreatic cancer

*PRI Rank #13 · Topics and Trends in Most Cited MicroRNA in disease regulation Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/microrna-in-disease-regulation/2026/rank-13*

| Field | Value |
| --- | --- |
| Rank | #13 |
| 18m citations | 42 |
| Journal | Signal Transduction and Targeted Therapy |
| Year | 2024 |
| DOI | 10.1038/s41392-024-01872-7 |
| Corresponding authors | Yewei Zhang |
| Institution | Affiliated Hospital of Nantong University, China |

**Ranking page:** [Topics and Trends in Most Cited MicroRNA in disease regulation Papers, Class of 2026](https://pri.pepkio.com/top-papers/microrna-in-disease-regulation/2026)

**Paper link:** [10.1038/s41392-024-01872-7](https://doi.org/10.1038/s41392-024-01872-7)

## Topics

Engineered extracellular vesicles · cancer-associated fibroblasts · CAF reprogramming · tumor microenvironment · pancreatic cancer · bone marrow mesenchymal stem cells · miR-138-5p · pirfenidone · integrin α5-targeting peptides · FERMT2-TGFBR1 complex · TGF-β signaling pathway · FERMT2-PYCR1 complex · proline-mediated collagen synthesis · orthotopic stroma-rich mouse model · patient-derived xenograft · gemcitabine perfusion · tumor hypoxia · chemotherapy sensitization · IEVs-PFD/138

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited MicroRNA in disease regulation Papers, Class of 2026. https://pri.pepkio.com/top-papers/microrna-in-disease-regulation/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```