# Exosomal miR-106a-5p from highly metastatic colorectal cancer cells drives liver metastasis by inducing macrophage M2 polarization in the tumor microenvironment

*PRI Rank #10 · Topics and Trends in Most Cited MicroRNA in disease regulation Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/microrna-in-disease-regulation/2026/rank-10*

| Field | Value |
| --- | --- |
| Rank | #10 |
| 18m citations | 46 |
| Journal | Journal of Experimental & Clinical Cancer Research |
| Year | 2024 |
| DOI | 10.1186/s13046-024-03204-7 |
| Corresponding authors | Taiyuan Li, Xiong Lei |
| Institution | Nanchang University, China |

**Ranking page:** [Topics and Trends in Most Cited MicroRNA in disease regulation Papers, Class of 2026](https://pri.pepkio.com/top-papers/microrna-in-disease-regulation/2026)

**Paper link:** [10.1186/s13046-024-03204-7](https://doi.org/10.1186/s13046-024-03204-7)

## Topics

exosomal miR-106a-5p · colorectal cancer liver metastasis · M2 macrophage polarization · Tumor microenvironment crosstalk · SOCS6 · JAK2/STAT3 pathway · hnRNPA1 · single-cell RNA sequencing · CD206 · exosome-mediated communication · miRNA pull-down · RNA immunoprecipitation · Luciferase reporter assay · plasma exosome biomarker · ultracentrifugation · nanoparticle tracking analysis · transmission electron microscopy · macrophage M2 phenotype · exosomal miRNA transport · liver metastasis model

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited MicroRNA in disease regulation Papers, Class of 2026. https://pri.pepkio.com/top-papers/microrna-in-disease-regulation/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```