# Evolution-inspired engineering of nonribosomal peptide synthetases

*PRI Rank #9 · Topics and Trends in Most Cited Microbial Natural Products and Biosynthesis Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/microbial-natural-products-and-biosynthesis/2026/rank-9*

| Field | Value |
| --- | --- |
| Rank | #9 |
| 18m citations | 56 |
| Journal | Science |
| Year | 2024 |
| DOI | 10.1126/science.adg4320 |
| Corresponding authors | Kenan A. J. Bozhüyük, Leonard Präve, Carsten Kegler, Leonie Schenk, Helge B. Bode |
| Institution | Max Planck Institute for Terrestrial Microbiology, Germany |

**Ranking page:** [Topics and Trends in Most Cited Microbial Natural Products and Biosynthesis Papers, Class of 2026](https://pri.pepkio.com/top-papers/microbial-natural-products-and-biosynthesis/2026)

**Paper link:** [10.1126/science.adg4320](https://doi.org/10.1126/science.adg4320)

## Topics

nonribosomal peptide synthetases · NRPS engineering · phylogenetic analysis · Thiolation domain · Thiolation domain · recombination sites · eXchange Unit between T domains · eXchange Unit between T domains · natural products · megasynthetases · assembly line biosynthesis · GC content · extender unit specificity · proteasome inhibitor · NRPS fragment assembly · module exchange · evolution-inspired design

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Microbial Natural Products and Biosynthesis Papers, Class of 2026. https://pri.pepkio.com/top-papers/microbial-natural-products-and-biosynthesis/2026. Accessed 2026-10-29.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```