# Natural Products Have Increased Rates of Clinical Trial Success throughout the Drug Development Process

*PRI Rank #8 · Topics and Trends in Most Cited Microbial Natural Products and Biosynthesis Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/microbial-natural-products-and-biosynthesis/2026/rank-8*

| Field | Value |
| --- | --- |
| Rank | #8 |
| 18m citations | 64 |
| Journal | Journal of Natural Products |
| Year | 2024 |
| DOI | 10.1021/acs.jnatprod.4c00581 |
| Corresponding authors | Daniel Domingo‐Fernándéz |
| Institution | Enveda Biosciences, United States |

**Ranking page:** [Topics and Trends in Most Cited Microbial Natural Products and Biosynthesis Papers, Class of 2026](https://pri.pepkio.com/top-papers/microbial-natural-products-and-biosynthesis/2026)

**Paper link:** [10.1021/acs.jnatprod.4c00581](https://doi.org/10.1021/acs.jnatprod.4c00581)

## Topics

natural products · clinical trial success rate · drug development process · NP-derived compounds · synthetic compounds · patent applications · clinical trial phases I to III · in vitro toxicity studies · in silico toxicity studies · drug approval · early-stage drug discovery · late-stage drug discovery · compound toxicity comparison · NP-based drug development

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Microbial Natural Products and Biosynthesis Papers, Class of 2026. https://pri.pepkio.com/top-papers/microbial-natural-products-and-biosynthesis/2026. Accessed 2026-10-29.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```