# Characterization and heterologous reconstitution of Taxus biosynthetic enzymes leading to baccatin III

*PRI Rank #3 · Topics and Trends in Most Cited Microbial Natural Products and Biosynthesis Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/microbial-natural-products-and-biosynthesis/2026/rank-3*

| Field | Value |
| --- | --- |
| Rank | #3 |
| 18m citations | 103 |
| Journal | Science |
| Year | 2024 |
| DOI | 10.1126/science.adj3484 |
| Corresponding authors | Bin Jiang, Lei Gao, Haijun Wang, Ya‐Ping Sun, Huan Wang, Xiaoguang Lei, Jianbin Yan |
| Institution | Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, China |

**Ranking page:** [Topics and Trends in Most Cited Microbial Natural Products and Biosynthesis Papers, Class of 2026](https://pri.pepkio.com/top-papers/microbial-natural-products-and-biosynthesis/2026)

**Paper link:** [10.1126/science.adj3484](https://doi.org/10.1126/science.adj3484)

## Topics

paclitaxel · baccatin III · Taxus mairei · taxane oxetanase 1 · TOT1 · cytochrome P450 · oxetane ring formation · oxidative rearrangement · T9αH1 · C9 position oxidation · taxusin biosynthesis pathway · diterpenoid · phenylisoserinoyl side chain · heterologous expression · tobacco · paclitaxel biosynthesis

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Microbial Natural Products and Biosynthesis Papers, Class of 2026. https://pri.pepkio.com/top-papers/microbial-natural-products-and-biosynthesis/2026. Accessed 2026-10-29.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```