# COCONUT 2.0: a comprehensive overhaul and curation of the collection of open natural products database

*PRI Rank #2 · Topics and Trends in Most Cited Microbial Natural Products and Biosynthesis Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/microbial-natural-products-and-biosynthesis/2026/rank-2*

| Field | Value |
| --- | --- |
| Rank | #2 |
| 18m citations | 104 |
| Journal | Nucleic Acids Research |
| Year | 2024 |
| DOI | 10.1093/nar/gkae1063 |
| Corresponding authors | Christoph Steinbeck |
| Institution | Friedrich Schiller University Jena, Germany |

**Ranking page:** [Topics and Trends in Most Cited Microbial Natural Products and Biosynthesis Papers, Class of 2026](https://pri.pepkio.com/top-papers/microbial-natural-products-and-biosynthesis/2026)

**Paper link:** [10.1093/nar/gkae1063](https://doi.org/10.1093/nar/gkae1063)

## Topics

COCONUT database · natural product databases · chemical structure aggregation · natural product curation · structure search · substructure search · similarity search · natural product synonyms · species occurrence data · geographic origin metadata · literature references · SDF format · CSV format · database dump · open-source web application · user data submission · community curation

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Microbial Natural Products and Biosynthesis Papers, Class of 2026. https://pri.pepkio.com/top-papers/microbial-natural-products-and-biosynthesis/2026. Accessed 2026-10-29.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```