# A widespread family of ribosomal peptide metallophores involved in bacterial adaptation to metal stress

*PRI Rank #17 · Topics and Trends in Most Cited Microbial Natural Products and Biosynthesis Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/microbial-natural-products-and-biosynthesis/2026/rank-17*

| Field | Value |
| --- | --- |
| Rank | #17 |
| 18m citations | 28 |
| Journal | Proceedings of the National Academy of Sciences |
| Year | 2024 |
| DOI | 10.1073/pnas.2408304121 |
| Corresponding authors | Laura Leprévost, Sophie Jünger, Guy Lippens, Rudy Antoine, Séverine Zirah, Svetlana Dubiley, Yanyan Li, Françoise Jacob‐Dubuisson |
| Institution | Univ. Lille, France |

**Ranking page:** [Topics and Trends in Most Cited Microbial Natural Products and Biosynthesis Papers, Class of 2026](https://pri.pepkio.com/top-papers/microbial-natural-products-and-biosynthesis/2026)

**Paper link:** [10.1073/pnas.2408304121](https://doi.org/10.1073/pnas.2408304121)

## Topics

bufferins · ribosomally synthesized and post-translationally modified peptides · ribosomally synthesized and post-translationally modified peptides · Multinuclear non-heme iron-dependent oxidative enzymes · Multinuclear non-heme iron-dependent oxidative enzymes · DUF692 · 5-thiooxazoles · thiooxazole heterocycles · DUF2063 family · Caulobacter vibrioides · N-terminal Sec signal peptide · Sec pathway · copper homeostasis · copper stress · metallophores · metal-binding · Post-translational modifications · biosynthetic gene cluster

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Microbial Natural Products and Biosynthesis Papers, Class of 2026. https://pri.pepkio.com/top-papers/microbial-natural-products-and-biosynthesis/2026. Accessed 2026-10-29.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```