# Effectiveness of molecular fingerprints for exploring the chemical space of natural products

*PRI Rank #14 · Topics and Trends in Most Cited Microbial Natural Products and Biosynthesis Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/microbial-natural-products-and-biosynthesis/2026/rank-14*

| Field | Value |
| --- | --- |
| Rank | #14 |
| 18m citations | 32 |
| Journal | Journal of Cheminformatics |
| Year | 2024 |
| DOI | 10.1186/s13321-024-00830-3 |
| Corresponding authors | Davide Boldini |
| Institution | Technical University of Munich, Germany |

**Ranking page:** [Topics and Trends in Most Cited Microbial Natural Products and Biosynthesis Papers, Class of 2026](https://pri.pepkio.com/top-papers/microbial-natural-products-and-biosynthesis/2026)

**Paper link:** [10.1186/s13321-024-00830-3](https://doi.org/10.1186/s13321-024-00830-3)

## Topics

natural products · molecular fingerprints · chemical space exploration · COCONUT database · CMNPD database · molecular fingerprints · bioactivity prediction · sp3-hybridized carbons · stereocenters · pairwise similarity · cheminformatics · fingerprint performance benchmarking · structural encoding · drug-like compounds · marine natural products

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Microbial Natural Products and Biosynthesis Papers, Class of 2026. https://pri.pepkio.com/top-papers/microbial-natural-products-and-biosynthesis/2026. Accessed 2026-10-29.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```