# Green synthesis of zinc oxide nanoparticles (ZnO-NPs) by Streptomyces baarnensis and its active metabolite (Ka): a promising combination against multidrug-resistant ESKAPE pathogens and cytotoxicity

*PRI Rank #13 · Topics and Trends in Most Cited Microbial Natural Products and Biosynthesis Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/microbial-natural-products-and-biosynthesis/2026/rank-13*

| Field | Value |
| --- | --- |
| Rank | #13 |
| 18m citations | 35 |
| Journal | BMC Microbiology |
| Year | 2024 |
| DOI | 10.1186/s12866-024-03392-4 |
| Corresponding authors | Gamal M. El-Sherbiny |
| Institution | Al-Azhar University, Egypt |

**Ranking page:** [Topics and Trends in Most Cited Microbial Natural Products and Biosynthesis Papers, Class of 2026](https://pri.pepkio.com/top-papers/microbial-natural-products-and-biosynthesis/2026)

**Paper link:** [10.1186/s12866-024-03392-4](https://doi.org/10.1186/s12866-024-03392-4)

## Topics

ZnO-NPs biosynthesis · Streptomyces baarnensis MH-133 · 9-Ethyl-1,4,6,9,10-pentahydroxy-7,8,9,10-tetrahydrotetracene-5,12-dione · Ka compound · zinc sulfate precursor · HR-TEM characterization · checkerboard microdilution · fractional inhibitory concentration index · Ka-ZnO-NPs nanoemulsion · Methicillin-resistant Staphylococcus aureus · Klebsiella pneumoniae · ESKAPE pathogens · killing kinetic assay · synergistic antibacterial activity · polydispersity index · VERO cell cytotoxicity · bactericidal effect · nanoemulsion formulation · Multidrug-resistant bacteria · X-ray crystal structure

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Microbial Natural Products and Biosynthesis Papers, Class of 2026. https://pri.pepkio.com/top-papers/microbial-natural-products-and-biosynthesis/2026. Accessed 2026-10-29.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```