# Cell-free biosynthesis and engineering of ribosomally synthesized lanthipeptides

*PRI Rank #12 · Topics and Trends in Most Cited Microbial Natural Products and Biosynthesis Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/microbial-natural-products-and-biosynthesis/2026/rank-12*

| Field | Value |
| --- | --- |
| Rank | #12 |
| 18m citations | 39 |
| Journal | Nature Communications |
| Year | 2024 |
| DOI | 10.1038/s41467-024-48726-y |
| Corresponding authors | Yifan Liu, Shengjie Ling, Michael C. Jewett, Jian Li |
| Institution | ShanghaiTech University, China |

**Ranking page:** [Topics and Trends in Most Cited Microbial Natural Products and Biosynthesis Papers, Class of 2026](https://pri.pepkio.com/top-papers/microbial-natural-products-and-biosynthesis/2026)

**Paper link:** [10.1038/s41467-024-48726-y](https://doi.org/10.1038/s41467-024-48726-y)

## Topics

ribosomally synthesized and post-translationally modified peptides · ribosomally synthesized and post-translationally modified peptides · lanthipeptides · cell-free biosynthesis · UniBioCat system · salivaricin B · de novo biosynthesis · Protease deletion · Protease deletion · antimicrobial activity screening · lanthipeptide variants · cell-free biosynthesis · heterologous expression · pathway reconstitution · RiPP biosynthetic gene clusters · natural product discovery

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Microbial Natural Products and Biosynthesis Papers, Class of 2026. https://pri.pepkio.com/top-papers/microbial-natural-products-and-biosynthesis/2026. Accessed 2026-10-29.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```