# Evolution-guided engineering of trans -acyltransferase polyketide synthases

*PRI Rank #11 · Topics and Trends in Most Cited Microbial Natural Products and Biosynthesis Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/microbial-natural-products-and-biosynthesis/2026/rank-11*

| Field | Value |
| --- | --- |
| Rank | #11 |
| 18m citations | 39 |
| Journal | Science |
| Year | 2024 |
| DOI | 10.1126/science.adj7621 |
| Corresponding authors | Mathijs F. J. Mabesoone, Stefan Leopold‐Messer, Hannah A. Minas, Jörn Piel |
| Institution | Eidgenössische Technische Hochschule (ETH) Zürich, Switzerland |

**Ranking page:** [Topics and Trends in Most Cited Microbial Natural Products and Biosynthesis Papers, Class of 2026](https://pri.pepkio.com/top-papers/microbial-natural-products-and-biosynthesis/2026)

**Paper link:** [10.1126/science.adj7621](https://doi.org/10.1126/science.adj7621)

## Topics

trans-acyltransferase polyketide synthases · trans-acyltransferase polyketide synthases · cis-acyltransferase PKSs · cis-acyltransferase PKSs · modular polyketide synthases · PKS modules · Co-evolution analysis · hybrid PKSs · module insertion · module deletion · PKS engineering · polyketide diversification · designer polyketides · natural products · assembly line enzymes · coevolution-guided engineering · module exchange site · pathway engineering

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Microbial Natural Products and Biosynthesis Papers, Class of 2026. https://pri.pepkio.com/top-papers/microbial-natural-products-and-biosynthesis/2026. Accessed 2026-10-29.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```