# MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration

*PRI Rank #1 · Topics and Trends in Most Cited Microbial Natural Products and Biosynthesis Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/microbial-natural-products-and-biosynthesis/2026/rank-1*

| Field | Value |
| --- | --- |
| Rank | #1 |
| 18m citations | 184 |
| Journal | Nucleic Acids Research |
| Year | 2024 |
| DOI | 10.1093/nar/gkae1115 |
| Corresponding authors | Mitja M Zdouc |
| Institution | Wageningen University & Research, Netherlands |

**Ranking page:** [Topics and Trends in Most Cited Microbial Natural Products and Biosynthesis Papers, Class of 2026](https://pri.pepkio.com/top-papers/microbial-natural-products-and-biosynthesis/2026)

**Paper link:** [10.1093/nar/gkae1115](https://doi.org/10.1093/nar/gkae1115)

## Topics

biosynthetic gene cluster · biosynthetic gene cluster · natural products · natural products · natural products · MIBiG database · Minimum Information about a Biosynthetic Gene cluster · MIBiG data standard · community annotation · automated data validation · peer-reviewing model · machine-readable data · BGC curation · rolling release model · submission portal · data quality · MIBiG database

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Microbial Natural Products and Biosynthesis Papers, Class of 2026. https://pri.pepkio.com/top-papers/microbial-natural-products-and-biosynthesis/2026. Accessed 2026-10-29.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```