# Engineered enzymes for the synthesis of pharmaceuticals and other high-value products

*PRI Rank #3 · Topics and Trends in Most Cited Microbial Metabolic Engineering and Bioproduction Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/microbial-metabolic-engineering-and-bioproduction/2026/rank-3*

| Field | Value |
| --- | --- |
| Rank | #3 |
| 18m citations | 94 |
| Journal | Nature Synthesis |
| Year | 2024 |
| DOI | 10.1038/s44160-023-00417-0 |
| Corresponding authors | Manfred T. Reetz, Ge Qu, Zhoutong Sun |
| Institution | Max-Planck-Institut für Kohlenforschung, Germany |

**Ranking page:** [Topics and Trends in Most Cited Microbial Metabolic Engineering and Bioproduction Papers, Class of 2026](https://pri.pepkio.com/top-papers/microbial-metabolic-engineering-and-bioproduction/2026)

**Paper link:** [10.1038/s44160-023-00417-0](https://doi.org/10.1038/s44160-023-00417-0)

## Topics

Enzyme engineering · Biocatalysis · Biocatalysis · Enzyme engineering · directed evolution · Enzyme engineering · stereoselective synthesis · green chemistry · chiral compounds · Biocatalysis

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Microbial Metabolic Engineering and Bioproduction Papers, Class of 2026. https://pri.pepkio.com/top-papers/microbial-metabolic-engineering-and-bioproduction/2026. Accessed 2026-07-29.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```