# Expanding chemistry through in vitro and in vivo biocatalysis

*PRI Rank #2 · Topics and Trends in Most Cited Microbial Metabolic Engineering and Bioproduction Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/microbial-metabolic-engineering-and-bioproduction/2026/rank-2*

| Field | Value |
| --- | --- |
| Rank | #2 |
| 18m citations | 112 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-07506-w |
| Corresponding authors | Michelle C. Y. Chang |
| Institution | University of California Berkeley, United States |

**Ranking page:** [Topics and Trends in Most Cited Microbial Metabolic Engineering and Bioproduction Papers, Class of 2026](https://pri.pepkio.com/top-papers/microbial-metabolic-engineering-and-bioproduction/2026)

**Paper link:** [10.1038/s41586-024-07506-w](https://doi.org/10.1038/s41586-024-07506-w)

## Topics

Biocatalysis · Biocatalysis · Biocatalysis · Synthetic biology · Metabolic engineering · Biocatalysis · Enzyme engineering · chemical diversity · Natural product biosynthesis · non-natural chemistry

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Microbial Metabolic Engineering and Bioproduction Papers, Class of 2026. https://pri.pepkio.com/top-papers/microbial-metabolic-engineering-and-bioproduction/2026. Accessed 2026-07-29.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```