# Yeast metabolism adaptation for efficient terpenoids synthesis via isopentenol utilization

*PRI Rank #18 · Topics and Trends in Most Cited Microbial Metabolic Engineering and Bioproduction Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/microbial-metabolic-engineering-and-bioproduction/2026/rank-18*

| Field | Value |
| --- | --- |
| Rank | #18 |
| 18m citations | 38 |
| Journal | Nature Communications |
| Year | 2024 |
| DOI | 10.1038/s41467-024-54298-8 |
| Corresponding authors | Yufei Cao, Wen‐Yong Lou |
| Institution | South China University of Technology, China |

**Ranking page:** [Topics and Trends in Most Cited Microbial Metabolic Engineering and Bioproduction Papers, Class of 2026](https://pri.pepkio.com/top-papers/microbial-metabolic-engineering-and-bioproduction/2026)

**Paper link:** [10.1038/s41467-024-54298-8](https://doi.org/10.1038/s41467-024-54298-8)

## Topics

Isoprenoid biosynthesis · isopentenol utilization pathway · Mevalonate pathway · Saccharomyces cerevisiae · isopentenol · energy metabolism inhibition · ATP cofactor · growth-coupled production · IUPD strain · Enzyme engineering · high-throughput screening · squalene · β-carotene · limonene · terpenoid precursors · Metabolic engineering

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Microbial Metabolic Engineering and Bioproduction Papers, Class of 2026. https://pri.pepkio.com/top-papers/microbial-metabolic-engineering-and-bioproduction/2026. Accessed 2026-07-29.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```