# Efficient synthesis of squalene by cytoplasmic-peroxisomal engineering and regulating lipid metabolism in Yarrowia lipolytica

*PRI Rank #16 · Topics and Trends in Most Cited Microbial Metabolic Engineering and Bioproduction Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/microbial-metabolic-engineering-and-bioproduction/2026/rank-16*

| Field | Value |
| --- | --- |
| Rank | #16 |
| 18m citations | 38 |
| Journal | Bioresource Technology |
| Year | 2024 |
| DOI | 10.1016/j.biortech.2024.130379 |
| Corresponding authors | Jingwen Zhou |
| Institution | Jiangnan University, China |

**Ranking page:** [Topics and Trends in Most Cited Microbial Metabolic Engineering and Bioproduction Papers, Class of 2026](https://pri.pepkio.com/top-papers/microbial-metabolic-engineering-and-bioproduction/2026)

**Paper link:** [10.1016/j.biortech.2024.130379](https://doi.org/10.1016/j.biortech.2024.130379)

## Topics

squalene · Yarrowia lipolytica · Succinic acid production · lipid metabolism regulation · Metabolic engineering · peroxisome · Isoprenoid biosynthesis · Mevalonate pathway · farnesyl diphosphate · squalene synthase · lipid accumulation · β-oxidation · Acetyl-CoA · Compartmentalization

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Microbial Metabolic Engineering and Bioproduction Papers, Class of 2026. https://pri.pepkio.com/top-papers/microbial-metabolic-engineering-and-bioproduction/2026. Accessed 2026-07-29.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```