# TRYing to evaluate production costs in microbial biotechnology

*PRI Rank #15 · Topics and Trends in Most Cited Microbial Metabolic Engineering and Bioproduction Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/microbial-metabolic-engineering-and-bioproduction/2026/rank-15*

| Field | Value |
| --- | --- |
| Rank | #15 |
| 18m citations | 40 |
| Journal | Trends in biotechnology |
| Year | 2024 |
| DOI | 10.1016/j.tibtech.2024.04.007 |
| Corresponding authors | Jens Nielsen |
| Institution | Chalmers University of Technology, Sweden |

**Ranking page:** [Topics and Trends in Most Cited Microbial Metabolic Engineering and Bioproduction Papers, Class of 2026](https://pri.pepkio.com/top-papers/microbial-metabolic-engineering-and-bioproduction/2026)

**Paper link:** [10.1016/j.tibtech.2024.04.007](https://doi.org/10.1016/j.tibtech.2024.04.007)

## Topics

titer, rate, and yield (TRY) · Fermentation · Techno-economic analysis · production cost evaluation · 1,3-propanediol (PDO) · Ethanol production · penicillin production · commodity chemicals · fine chemicals · process economics · Fermentation · Bioprocessing

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Microbial Metabolic Engineering and Bioproduction Papers, Class of 2026. https://pri.pepkio.com/top-papers/microbial-metabolic-engineering-and-bioproduction/2026. Accessed 2026-07-29.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```