# Unlocking the potential of enzyme engineering via rational computational design strategies

*PRI Rank #11 · Topics and Trends in Most Cited Microbial Metabolic Engineering and Bioproduction Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/microbial-metabolic-engineering-and-bioproduction/2026/rank-11*

| Field | Value |
| --- | --- |
| Rank | #11 |
| 18m citations | 48 |
| Journal | Biotechnology Advances |
| Year | 2024 |
| DOI | 10.1016/j.biotechadv.2024.108376 |
| Corresponding authors | Jia Wang, Qipeng Yuan |
| Institution | Beijing University of Chemical Technology, China |

**Ranking page:** [Topics and Trends in Most Cited Microbial Metabolic Engineering and Bioproduction Papers, Class of 2026](https://pri.pepkio.com/top-papers/microbial-metabolic-engineering-and-bioproduction/2026)

**Paper link:** [10.1016/j.biotechadv.2024.108376](https://doi.org/10.1016/j.biotechadv.2024.108376)

## Topics

Enzyme engineering · rational computational design · Enzyme engineering · Structure-based design · directed evolution · Enzyme engineering · Enzyme optimization · active site engineering · molecular dynamics simulations · quantum mechanics/molecular mechanics · binding affinity prediction · Enzyme optimization · Enzyme optimization · Machine learning for enzyme design · Rosetta · FoldX · enzyme promiscuity · Biocatalysis

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Microbial Metabolic Engineering and Bioproduction Papers, Class of 2026. https://pri.pepkio.com/top-papers/microbial-metabolic-engineering-and-bioproduction/2026. Accessed 2026-07-29.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```