# Motion of VAPB molecules reveals ER–mitochondria contact site subdomains

*PRI Rank #8 · Topics and Trends in Most Cited Metabolism and Genetic Disorders Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/metabolism-and-genetic-disorders/2026/rank-8*

| Field | Value |
| --- | --- |
| Rank | #8 |
| 18m citations | 54 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-023-06956-y |
| Corresponding authors | Christopher J. Obara, Jennifer Lippincott‐Schwartz |
| Institution | Janelia Research Campus, United States |

**Ranking page:** [Topics and Trends in Most Cited Metabolism and Genetic Disorders Papers, Class of 2026](https://pri.pepkio.com/top-papers/metabolism-and-genetic-disorders/2026)

**Paper link:** [10.1038/s41586-023-06956-y](https://doi.org/10.1038/s41586-023-06956-y)

## Topics

VAPB · ER-mitochondria contact sites · Organelle tethering · single-molecule tracking · three-dimensional electron microscopy · ER membrane curvature · Contact site remodelling · protein diffusion landscape · VAPB P56S mutation · VAPB P56S mutation · Contact site remodelling · interorganelle communication · high-speed molecular imaging · membrane interface nanoscale organization · Contact site remodelling · lipid and metabolite exchange · organelle contact site homeostasis · molecular tether dynamics · ER morphology · Mitochondria-associated membranes

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Metabolism and Genetic Disorders Papers, Class of 2026. https://pri.pepkio.com/top-papers/metabolism-and-genetic-disorders/2026. Accessed 2026-07-24.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```