# Lentiviral Gene Therapy for Cerebral Adrenoleukodystrophy

*PRI Rank #7 · Topics and Trends in Most Cited Metabolism and Genetic Disorders Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/metabolism-and-genetic-disorders/2026/rank-7*

| Field | Value |
| --- | --- |
| Rank | #7 |
| 18m citations | 64 |
| Journal | New England Journal of Medicine |
| Year | 2024 |
| DOI | 10.1056/nejmoa2400442 |
| Corresponding authors | Florian Eichler |
| Institution | Massachusetts General Hospital, United States |

**Ranking page:** [Topics and Trends in Most Cited Metabolism and Genetic Disorders Papers, Class of 2026](https://pri.pepkio.com/top-papers/metabolism-and-genetic-disorders/2026)

**Paper link:** [10.1056/nejmoa2400442](https://doi.org/10.1056/nejmoa2400442)

## Topics

cerebral adrenoleukodystrophy · lentiviral gene therapy · eli-cel · ABCD1 gene · hematopoietic stem cells · major functional disabilities · neurologic function score · magnetic resonance imaging · active inflammation · insertional oncogenesis · myelodysplastic syndrome · allogeneic hematopoietic stem-cell transplantation · viral vector integration · long-term follow-up · Phase 2-3 trial

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Metabolism and Genetic Disorders Papers, Class of 2026. https://pri.pepkio.com/top-papers/metabolism-and-genetic-disorders/2026. Accessed 2026-07-24.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```