# Interim analyses of a first-in-human phase 1/2 mRNA trial for propionic acidaemia

*PRI Rank #4 · Topics and Trends in Most Cited Metabolism and Genetic Disorders Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/metabolism-and-genetic-disorders/2026/rank-4*

| Field | Value |
| --- | --- |
| Rank | #4 |
| 18m citations | 77 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-07266-7 |
| Corresponding authors | Stephanie Grünewald |
| Institution | Duke University, United States |

**Ranking page:** [Topics and Trends in Most Cited Metabolism and Genetic Disorders Papers, Class of 2026](https://pri.pepkio.com/top-papers/metabolism-and-genetic-disorders/2026)

**Paper link:** [10.1038/s41586-024-07266-7](https://doi.org/10.1038/s41586-024-07266-7)

## Topics

Propionic acidemia · mRNA-3927 · Propionyl-CoA carboxylase · Propionyl-CoA carboxylase · Propionyl-CoA carboxylase · dual mRNA therapy · metabolic decompensation events · dose-optimization study · first-in-human phase 1/2 trial · intravenous mRNA dosing · dose escalation · dose-limiting toxicities · treatment-emergent adverse events · extension study · toxic metabolite accumulation · mRNA exposure pharmacokinetics

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Metabolism and Genetic Disorders Papers, Class of 2026. https://pri.pepkio.com/top-papers/metabolism-and-genetic-disorders/2026. Accessed 2026-07-24.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```