# A spatial map of hepatic mitochondria uncovers functional heterogeneity shaped by nutrient-sensing signaling

*PRI Rank #20 · Topics and Trends in Most Cited Metabolism and Genetic Disorders Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/metabolism-and-genetic-disorders/2026/rank-20*

| Field | Value |
| --- | --- |
| Rank | #20 |
| 18m citations | 30 |
| Journal | Nature Communications |
| Year | 2024 |
| DOI | 10.1038/s41467-024-45751-9 |
| Corresponding authors | Natalie Porat‐Shliom |
| Institution | National Cancer Institute, United States |

**Ranking page:** [Topics and Trends in Most Cited Metabolism and Genetic Disorders Papers, Class of 2026](https://pri.pepkio.com/top-papers/metabolism-and-genetic-disorders/2026)

**Paper link:** [10.1038/s41467-024-45751-9](https://doi.org/10.1038/s41467-024-45751-9)

## Topics

Mitochondrial heterogeneity · Liver metabolic zonation · Liver metabolic zonation · intravital microscopy · spatial proteomics · comparative phosphoproteomics · mitochondrial morphology · beta-oxidation · lipid synthesis · nutrient-sensing signaling · AMPK signaling · mTOR signaling · mitochondrial phosphorylation · mitochondrial homeostasis · Liver metabolic zonation · mitochondrial functional assessment · mitochondrial composition mapping · Liver metabolic zonation · pharmacological modulation of nutrient sensing · mitochondrial structure-function regulation

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Metabolism and Genetic Disorders Papers, Class of 2026. https://pri.pepkio.com/top-papers/metabolism-and-genetic-disorders/2026. Accessed 2026-07-24.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```