# Hexokinase 1 forms rings that regulate mitochondrial fission during energy stress

*PRI Rank #18 · Topics and Trends in Most Cited Metabolism and Genetic Disorders Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/metabolism-and-genetic-disorders/2026/rank-18*

| Field | Value |
| --- | --- |
| Rank | #18 |
| 18m citations | 31 |
| Journal | Molecular Cell |
| Year | 2024 |
| DOI | 10.1016/j.molcel.2024.06.009 |
| Corresponding authors | Roland Malli |
| Institution | Medical University of Graz, Austria |

**Ranking page:** [Topics and Trends in Most Cited Metabolism and Genetic Disorders Papers, Class of 2026](https://pri.pepkio.com/top-papers/metabolism-and-genetic-disorders/2026)

**Paper link:** [10.1016/j.molcel.2024.06.009](https://doi.org/10.1016/j.molcel.2024.06.009)

## Topics

Hexokinase 1 (HK1) · HK1-rings · Mitochondrial fission · energy stress sensing · ER-mitochondria contact sites · mitochondrial dynamics protein (MiD51) · dynamin-related protein 1 (DRP1) · mitochondrial fission factor (Mff) · mitochondrial fission 1 protein (Fis1) · ATP depletion · glucose-6-phosphate (G6P) · glycolytic enzyme regulation · TCA cycle activity · mitochondrial constriction · mitochondrial shape regulation · mitochondrial connectivity · Metabolic reprogramming · ring-forming mutations

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Metabolism and Genetic Disorders Papers, Class of 2026. https://pri.pepkio.com/top-papers/metabolism-and-genetic-disorders/2026. Accessed 2026-07-24.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```