# Hierarchical tricarboxylic acid cycle regulation by hepatocyte arginase 2 links the urea cycle to oxidative metabolism

*PRI Rank #17 · Topics and Trends in Most Cited Metabolism and Genetic Disorders Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/metabolism-and-genetic-disorders/2026/rank-17*

| Field | Value |
| --- | --- |
| Rank | #17 |
| 18m citations | 32 |
| Journal | Cell Metabolism |
| Year | 2024 |
| DOI | 10.1016/j.cmet.2024.07.007 |
| Corresponding authors | Brian J. DeBosch |
| Institution | Washington University School of Medicine, United States |

**Ranking page:** [Topics and Trends in Most Cited Metabolism and Genetic Disorders Papers, Class of 2026](https://pri.pepkio.com/top-papers/metabolism-and-genetic-disorders/2026)

**Paper link:** [10.1016/j.cmet.2024.07.007](https://doi.org/10.1016/j.cmet.2024.07.007)

## Topics

Hepatocyte-specific arginase 2 knockout · Hepatocyte-specific arginase 2 knockout · Urea cycle disorder · TCA cycle flux · Metabolic tracing · respirometry · Oxidative metabolism · glutamine anaplerosis · diet-induced obesity · nicotinamide adenine dinucleotide (NAD) repletion · hepatic lipid derangement · glucose homeostasis · fibroinflammatory liver disease · biomarker-based disease prediction · urea-TCA cycle crosstalk · hierarchical metabolic regulation · hepatocyte metabolism · middle adulthood metabolic decline · serum metabolite biomarkers · compensated urea cycle defect

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Metabolism and Genetic Disorders Papers, Class of 2026. https://pri.pepkio.com/top-papers/metabolism-and-genetic-disorders/2026. Accessed 2026-07-24.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```