# The hidden impact of in-source fragmentation in metabolic and chemical mass spectrometry data interpretation

*PRI Rank #13 · Topics and Trends in Most Cited Metabolism and Genetic Disorders Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/metabolism-and-genetic-disorders/2026/rank-13*

| Field | Value |
| --- | --- |
| Rank | #13 |
| 18m citations | 37 |
| Journal | Nature Metabolism |
| Year | 2024 |
| DOI | 10.1038/s42255-024-01076-x |
| Corresponding authors | Martin Giera, Gary Siuzdak |
| Institution | Leiden University Medical Center, Netherlands |

**Ranking page:** [Topics and Trends in Most Cited Metabolism and Genetic Disorders Papers, Class of 2026](https://pri.pepkio.com/top-papers/metabolism-and-genetic-disorders/2026)

**Paper link:** [10.1038/s42255-024-01076-x](https://doi.org/10.1038/s42255-024-01076-x)

## Topics

in-source fragmentation · mass spectrometry data interpretation · metabolomics · Compound identification · spectral annotation false positives · adduct formation · fragment ion misassignment · Liquid chromatography-mass spectrometry · untargeted metabolomics workflows · molecular network analysis · Spectral library · Compound identification · data quality control in MS · isomer differentiation · annotation confidence

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Metabolism and Genetic Disorders Papers, Class of 2026. https://pri.pepkio.com/top-papers/metabolism-and-genetic-disorders/2026. Accessed 2026-07-24.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```