# <i>APOE3</i> Christchurch Heterozygosity and Autosomal Dominant Alzheimer’s Disease

*PRI Rank #12 · Topics and Trends in Most Cited Metabolism and Genetic Disorders Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/metabolism-and-genetic-disorders/2026/rank-12*

| Field | Value |
| --- | --- |
| Rank | #12 |
| 18m citations | 41 |
| Journal | New England Journal of Medicine |
| Year | 2024 |
| DOI | 10.1056/nejmoa2308583 |
| Corresponding authors | Yakeel T Quiroz |
| Institution | Massachusetts General Hospital, United States |

**Ranking page:** [Topics and Trends in Most Cited Metabolism and Genetic Disorders Papers, Class of 2026](https://pri.pepkio.com/top-papers/metabolism-and-genetic-disorders/2026)

**Paper link:** [10.1056/nejmoa2308583](https://doi.org/10.1056/nejmoa2308583)

## Topics

APOE3 Christchurch variant · Autosomal dominant Alzheimer's disease · Heterozygosity · PSEN1 mutation kindred · Brain imaging · Neuropathological autopsy · Amyloid pathology · tau pathology · Cognitive resilience · Age of disease onset

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Metabolism and Genetic Disorders Papers, Class of 2026. https://pri.pepkio.com/top-papers/metabolism-and-genetic-disorders/2026. Accessed 2026-07-24.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```