# Cellular ATP demand creates metabolically distinct subpopulations of mitochondria

*PRI Rank #1 · Topics and Trends in Most Cited Metabolism and Genetic Disorders Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/metabolism-and-genetic-disorders/2026/rank-1*

| Field | Value |
| --- | --- |
| Rank | #1 |
| 18m citations | 221 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-08146-w |
| Corresponding authors | Craig B. Thompson |
| Institution | Memorial Sloan Kettering Cancer Center, United States |

**Ranking page:** [Topics and Trends in Most Cited Metabolism and Genetic Disorders Papers, Class of 2026](https://pri.pepkio.com/top-papers/metabolism-and-genetic-disorders/2026)

**Paper link:** [10.1038/s41586-024-08146-w](https://doi.org/10.1038/s41586-024-08146-w)

## Topics

cellular ATP demand · Mitochondrial heterogeneity · mitochondria · Mitochondrial heterogeneity · ATP production · Metabolic compartmentalization · bioenergetics · Mitochondrial heterogeneity · Energy metabolism · mitochondrial function

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Metabolism and Genetic Disorders Papers, Class of 2026. https://pri.pepkio.com/top-papers/metabolism-and-genetic-disorders/2026. Accessed 2026-07-24.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```