# Exosomes from hypoxic urine-derived stem cells facilitate healing of diabetic wound by targeting SERPINE1 through miR-486-5p

*PRI Rank #9 · Topics and Trends in Most Cited Mesenchymal stem cell research Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/mesenchymal-stem-cell-research/2026/rank-9*

| Field | Value |
| --- | --- |
| Rank | #9 |
| 18m citations | 52 |
| Journal | Biomaterials |
| Year | 2024 |
| DOI | 10.1016/j.biomaterials.2024.122893 |
| Corresponding authors | Huiqi Xie |
| Institution | Sichuan University, China |

**Ranking page:** [Topics and Trends in Most Cited Mesenchymal stem cell research Papers, Class of 2026](https://pri.pepkio.com/top-papers/mesenchymal-stem-cell-research/2026)

**Paper link:** [10.1016/j.biomaterials.2024.122893](https://doi.org/10.1016/j.biomaterials.2024.122893)

## Topics

urine-derived stem cells · Hypoxic preconditioning · Exosomes/Extracellular vesicles · miR-486-5p · SERPINE1 · diabetic wound healing · Angiogenesis · dECM hydrogel · SISMA hydrogel · Small intestinal submucosa · endothelial cell proliferation · endothelial cell migration · Tube formation assay · Angiogenesis · HIF-1α signaling pathway · miRNA sequencing · exosome delivery · Cell-free therapy

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Mesenchymal stem cell research Papers, Class of 2026. https://pri.pepkio.com/top-papers/mesenchymal-stem-cell-research/2026. Accessed 2026-07-31.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```