# Generation of complex bone marrow organoids from human induced pluripotent stem cells

*PRI Rank #3 · Topics and Trends in Most Cited Mesenchymal stem cell research Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/mesenchymal-stem-cell-research/2026/rank-3*

| Field | Value |
| --- | --- |
| Rank | #3 |
| 18m citations | 69 |
| Journal | Nature Methods |
| Year | 2024 |
| DOI | 10.1038/s41592-024-02172-2 |
| Corresponding authors | Christoph Klein |
| Institution | Ludwig-Maximilians-University Munich, Germany |

**Ranking page:** [Topics and Trends in Most Cited Mesenchymal stem cell research Papers, Class of 2026](https://pri.pepkio.com/top-papers/mesenchymal-stem-cell-research/2026)

**Paper link:** [10.1038/s41592-024-02172-2](https://doi.org/10.1038/s41592-024-02172-2)

## Topics

bone marrow organoids · human induced pluripotent stem cells · Bone marrow microenvironment · Mesenchymal stem cells · neutrophil differentiation · Single-cell RNA sequencing · hematopoietic stem/progenitor cells · fetal HSCs · lymphoid potential · xenotransplantation · VPS45 deficiency · three-dimensional self-organization · vascular network · inflammatory stimuli responsiveness · inborn errors of hematopoiesis · hematopoietic development modeling

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Mesenchymal stem cell research Papers, Class of 2026. https://pri.pepkio.com/top-papers/mesenchymal-stem-cell-research/2026. Accessed 2026-07-31.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```