# Exosomes loaded a smart bilayer-hydrogel scaffold with ROS-scavenging and macrophage-reprogramming properties for repairing cartilage defect

*PRI Rank #17 · Topics and Trends in Most Cited Mesenchymal stem cell research Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/mesenchymal-stem-cell-research/2026/rank-17*

| Field | Value |
| --- | --- |
| Rank | #17 |
| 18m citations | 33 |
| Journal | Bioactive Materials |
| Year | 2024 |
| DOI | 10.1016/j.bioactmat.2024.04.017 |
| Corresponding authors | Shishuo Li, Ningbo Li, Ningbo Li, Zhentao Man, Bing Liu, Wei Li |
| Institution | Shandong Provincial Hospital Affiliated to Shandong First Medical University, China |

**Ranking page:** [Topics and Trends in Most Cited Mesenchymal stem cell research Papers, Class of 2026](https://pri.pepkio.com/top-papers/mesenchymal-stem-cell-research/2026)

**Paper link:** [10.1016/j.bioactmat.2024.04.017](https://doi.org/10.1016/j.bioactmat.2024.04.017)

## Topics

Exosomes/Extracellular vesicles · bilayer-hydrogel scaffold · ROS scavenging · Macrophage polarization · Cartilage repair · Reactive oxygen species · sodium diclofenac · Bone marrow mesenchymal stem cells · phenylboronic-acid-crosslinked polyvinyl alcohol · ROS-responsive degradation · hyaluronic acid hydrogel · Chondrogenesis · stem cell recruitment · Chondrogenesis · oxidative stress mitigation · post-traumatic inflammation · Macrophage polarization · Cell-free therapy · multi-staged therapeutic delivery · Cartilage repair

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Mesenchymal stem cell research Papers, Class of 2026. https://pri.pepkio.com/top-papers/mesenchymal-stem-cell-research/2026. Accessed 2026-07-31.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```