# Engineering exosomes derived from TNF-α preconditioned IPFP-MSCs enhance both yield and therapeutic efficacy for osteoarthritis

*PRI Rank #11 · Topics and Trends in Most Cited Mesenchymal stem cell research Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/mesenchymal-stem-cell-research/2026/rank-11*

| Field | Value |
| --- | --- |
| Rank | #11 |
| 18m citations | 48 |
| Journal | Journal of Nanobiotechnology |
| Year | 2024 |
| DOI | 10.1186/s12951-024-02795-9 |
| Corresponding authors | Yongqian Wang, Siru Zhou, Zhenhong Ni |
| Institution | Chinese Academy of Medical Sciences and Peking Union Medical College, China |

**Ranking page:** [Topics and Trends in Most Cited Mesenchymal stem cell research Papers, Class of 2026](https://pri.pepkio.com/top-papers/mesenchymal-stem-cell-research/2026)

**Paper link:** [10.1186/s12951-024-02795-9](https://doi.org/10.1186/s12951-024-02795-9)

## Topics

TNF-α preconditioning · IPFP-MSCs · MSC-derived exosomes · Osteoarthritis · exosome yield optimization · PI3K/AKT signaling pathway · ATG16L1 · ATG16L1 · exosome secretion · Intra-articular injection · Cartilage degradation · LRP1 · LRP1 · chondroprotective effects · RNA sequencing · Proteomics · pro-inflammatory preconditioning · cartilage homeostasis · OA mouse model

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Mesenchymal stem cell research Papers, Class of 2026. https://pri.pepkio.com/top-papers/mesenchymal-stem-cell-research/2026. Accessed 2026-07-31.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```