# The public health impact and cost-effectiveness of the R21/Matrix-M malaria vaccine: a mathematical modelling study

*PRI Rank #19 · Topics and Trends in Most Cited Malaria Research and Control Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/malaria-research-and-control/2026/rank-19*

| Field | Value |
| --- | --- |
| Rank | #19 |
| 18m citations | 27 |
| Journal | The Lancet Infectious Diseases |
| Year | 2024 |
| DOI | 10.1016/s1473-3099(23)00816-2 |
| Corresponding authors | Nora Schmit |
| Institution | Imperial College London, United Kingdom |

**Ranking page:** [Topics and Trends in Most Cited Malaria Research and Control Papers, Class of 2026](https://pri.pepkio.com/top-papers/malaria-research-and-control/2026)

**Paper link:** [10.1016/s1473-3099(23)00816-2](https://doi.org/10.1016/s1473-3099(23)00816-2)

## Topics

R21/Matrix-M vaccine · Plasmodium falciparum · anti-circumsporozoite antibodies · surrogate of protection · semi-mechanistic model · mathematical transmission model · phase 2b trial · phase 3 trial · Nanoro, Burkina Faso · parasite prevalence in children aged 2–10 years · four-dose regimen · age-based implementation · seasonal implementation · perennial settings · disability-adjusted life-years · cost-effectiveness · incremental cost per DALY averted · vaccine dose price · sub-Saharan Africa · clinical malaria

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Malaria Research and Control Papers, Class of 2026. https://pri.pepkio.com/top-papers/malaria-research-and-control/2026. Accessed 2026-07-23.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```