# Tirzepatide for Metabolic Dysfunction–Associated Steatohepatitis with Liver Fibrosis

*PRI Rank #2 · Topics and Trends in Most Cited Liver Disease Diagnosis and Treatment Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/liver-disease-diagnosis-and-treatment/2026/rank-2*

| Field | Value |
| --- | --- |
| Rank | #2 |
| 18m citations | 528 |
| Journal | New England Journal of Medicine |
| Year | 2024 |
| DOI | 10.1056/nejmoa2401943 |
| Corresponding authors | Rohit Loomba |
| Institution | University of California at San Diego, United States |

**Ranking page:** [Topics and Trends in Most Cited Liver Disease Diagnosis and Treatment Papers, Class of 2026](https://pri.pepkio.com/top-papers/liver-disease-diagnosis-and-treatment/2026)

**Paper link:** [10.1056/nejmoa2401943](https://doi.org/10.1056/nejmoa2401943)

## Topics

tirzepatide · Steatohepatitis · Steatohepatitis · Liver fibrosis · glucose-dependent insulinotropic polypeptide receptor · GIP receptor agonist · GLP-1 receptor · GLP-1 receptor agonists · dual agonist · Fibrosis stage F2 · Fibrosis stage F3 · Steatohepatitis resolution · Liver fibrosis improvement · liver biopsy · Subcutaneous administration · dose-finding trial · 52-week treatment · gastrointestinal adverse events

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Liver Disease Diagnosis and Treatment Papers, Class of 2026. https://pri.pepkio.com/top-papers/liver-disease-diagnosis-and-treatment/2026. Accessed 2026-07-24.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```