# The underappreciated diversity of bile acid modifications

*PRI Rank #17 · Topics and Trends in Most Cited Liver Disease Diagnosis and Treatment Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/liver-disease-diagnosis-and-treatment/2026/rank-17*

| Field | Value |
| --- | --- |
| Rank | #17 |
| 18m citations | 118 |
| Journal | Cell |
| Year | 2024 |
| DOI | 10.1016/j.cell.2024.02.019 |
| Corresponding authors | Pieter C. Dorrestein |
| Institution | University of California, San Diego, United States |

**Ranking page:** [Topics and Trends in Most Cited Liver Disease Diagnosis and Treatment Papers, Class of 2026](https://pri.pepkio.com/top-papers/liver-disease-diagnosis-and-treatment/2026)

**Paper link:** [10.1016/j.cell.2024.02.019](https://doi.org/10.1016/j.cell.2024.02.019)

## Topics

bile acid modifications · tandem mass spectrometry (MS/MS) · MS/MS spectral library · bile-acid-selective ion patterns · public untargeted metabolomics data mining · polyamine bile amidates · carnivore bile acid metabolism · microbial bile acid metabolism · Mediterranean diet · Western diet · diet-induced metabolite changes · steroidal lipids · host-microbiome co-metabolism · metabolite discovery from public spectral repositories · modification-centric metabolite annotation · bile acid diversity

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Liver Disease Diagnosis and Treatment Papers, Class of 2026. https://pri.pepkio.com/top-papers/liver-disease-diagnosis-and-treatment/2026. Accessed 2026-07-24.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```