# Data-driven cluster analysis identifies distinct types of metabolic dysfunction-associated steatotic liver disease

*PRI Rank #16 · Topics and Trends in Most Cited Liver Disease Diagnosis and Treatment Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/liver-disease-diagnosis-and-treatment/2026/rank-16*

| Field | Value |
| --- | --- |
| Rank | #16 |
| 18m citations | 130 |
| Journal | Nature Medicine |
| Year | 2024 |
| DOI | 10.1038/s41591-024-03283-1 |
| Corresponding authors | Stefano Romeo, François Pattou |
| Institution | University of Lille, France |

**Ranking page:** [Topics and Trends in Most Cited Liver Disease Diagnosis and Treatment Papers, Class of 2026](https://pri.pepkio.com/top-papers/liver-disease-diagnosis-and-treatment/2026)

**Paper link:** [10.1038/s41591-024-03283-1](https://doi.org/10.1038/s41591-024-03283-1)

## Topics

Metabolic dysfunction-associated steatotic liver disease · Metabolic dysfunction-associated steatotic liver disease · partitioning around medoids clustering · phenotypic heterogeneity · Steatohepatitis · liver-specific cluster · Cardiometabolic disease · Disease progression · cardiovascular disease risk · type 2 diabetes incidence · dysglycemia · Triglyceride metabolism · liver transcriptomics · metabolomic profiling · UK Biobank · liver biopsy · genetic linkage · clinical trajectories · obesity cohort · precision medicine

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Liver Disease Diagnosis and Treatment Papers, Class of 2026. https://pri.pepkio.com/top-papers/liver-disease-diagnosis-and-treatment/2026. Accessed 2026-07-24.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```