# Genome-wide characterization of circulating metabolic biomarkers

*PRI Rank #15 · Topics and Trends in Most Cited Liver Disease Diagnosis and Treatment Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/liver-disease-diagnosis-and-treatment/2026/rank-15*

| Field | Value |
| --- | --- |
| Rank | #15 |
| 18m citations | 151 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-07148-y |
| Corresponding authors | Minna K. Karjalainen |
| Institution | University of Oulu, Finland |

**Ranking page:** [Topics and Trends in Most Cited Liver Disease Diagnosis and Treatment Papers, Class of 2026](https://pri.pepkio.com/top-papers/liver-disease-diagnosis-and-treatment/2026)

**Paper link:** [10.1038/s41586-024-07148-y](https://doi.org/10.1038/s41586-024-07148-y)

## Topics

nuclear magnetic resonance spectroscopy · GWAS · circulating metabolic traits · lipoprotein metabolism · lipid-associated variants · genetic pleiotropy · Mendelian randomization · intrahepatic cholestasis of pregnancy · acetone · hypertension · causal gene assignment · high-throughput metabolomics · lipid loci · metabolomic profiling · independent loci · systemic metabolism · genetic determinants · lipid-associated variants · molecular phenotyping

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Liver Disease Diagnosis and Treatment Papers, Class of 2026. https://pri.pepkio.com/top-papers/liver-disease-diagnosis-and-treatment/2026. Accessed 2026-07-24.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```